Regulatory light chain of myosin. Does not bind calcium. Defects in MYL3 are the cause of familial hypertrophic cardiomyopathy type 8 (CMH8). Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. CMH8 inheritance can be autosomal dominant or recessive. Note: This description may include information from UniProtKB.
Cellular Component: A band; cytosol; I band; muscle myosin complex; sarcomere
Molecular Function: actin monomer binding; structural constituent of muscle
Biological Process: cardiac muscle contraction; muscle filament sliding; positive regulation of ATPase activity; regulation of striated muscle contraction; regulation of the force of heart contraction; ventricular cardiac muscle morphogenesis