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Protein Page:

K6a a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Associates with K16 and/or -17. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component: cytosol; intermediate filament; keratin filament
Molecular Function: protein binding; structural molecule activity
Biological Process: intermediate filament cytoskeleton organization and biogenesis; keratinization
Disease: Pachyonychia Congenita 3
Reference #:  P02538 (UniProtKB)
Alt. Names/Synonyms: 56 cytoskeletal type II keratin; CK-6A; CK-6D; CK6A; CK6C; CK6D; cytokeratin 6A; cytokeratin 6C; cytokeratin 6D; Cytokeratin-6A; Cytokeratin-6D; K2C6A; K6A; K6C; K6D; K6D keratin; keratin 6A; keratin 6C; keratin, epidermal type II, K6A; keratin, epidermal type II, K6C; Keratin, type II cytoskeletal 6A; keratin, type II cytoskeletal 6D; Keratin-6A; KRT6A; KRT6C; KRT6D; type II keratin isoform K6c; Type-II keratin Kb6
Gene Symbols: KRT6A
Molecular weight: 60,045 Da
Basal Isoelectric point: 8.09  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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