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EDG-1 a G protein-coupled receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Highly expressed in endothelial cells and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin. Suggested to be involved in the processes that regulate the migration/differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. S1P-induced endothelial cell migration requires AKT1-mediated phosphorylation of the third intracellular loop. Seems to be coupled to the G(i) subclass of heteromeric G proteins. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 3|3 G1
Cellular Component: external side of plasma membrane; intracellular membrane-bound organelle; intrinsic to plasma membrane; nucleoplasm
Molecular Function: G-protein coupled receptor activity; G-protein-coupled receptor binding; sphingolipid binding
Biological Process: actin cytoskeleton reorganization; angiogenesis; blood vessel maturation; brain development; cell migration; chemotaxis; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; lamellipodium biogenesis; leukocyte chemotaxis; negative regulation of stress fiber formation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of GTPase activity; positive regulation of positive chemotaxis; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of bone mineralization; regulation of bone resorption; regulation of cell adhesion
Reference #:  O08530 (UniProtKB)
Alt. Names/Synonyms: AI849002; Edg1; Endothelial differentiation G-protein coupled receptor 1; endothelial differentiation sphingolipid G-protein-coupled receptor 1; Lpb1; Lysophospholipid receptor B1; S1p; S1P receptor 1; S1P receptor Edg-1; S1P1; S1pr1; Sphingosine 1-phosphate receptor 1; Sphingosine 1-phosphate receptor Edg-1; sphingosine-1-phosphate receptor 1
Gene Symbols: S1pr1
Molecular weight: 42,639 Da
Basal Isoelectric point: 9.52  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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