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BRSK2 a serine/threonine protein kinase of the CAMK group. Closely related to AMPK. Activated by the kinase LKB1. BRSK1 and BRSK2 are required for nueronal polarization. Expressed in the brain and at low levels in the testis. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: BRSK subfamily; CAMK group; CAMKL family; EC; EC; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: centrosome; cytoplasm; endoplasmic reticulum; nucleus
Molecular Function: ATP binding; ATPase binding; magnesium ion binding; protein serine/threonine kinase activity; tau-protein kinase activity
Biological Process: actin cytoskeleton reorganization; axonogenesis; establishment of cell polarity; G2/M transition of mitotic cell cycle; neuron differentiation; protein amino acid phosphorylation
Reference #:  Q8IWQ3 (UniProtKB)
Alt. Names/Synonyms: BR serine/threonine kinase 2; BR serine/threonine-protein kinase 2; BRSK2; C11orf7; FLJ41362; PEN11B; protein kinase SAD1B; SAD1; serine/threonine kinase 29; serine/threonine kinase SAD-A; Serine/threonine-protein kinase 29; Serine/threonine-protein kinase SAD-A; STK29
Gene Symbols: BRSK2
Molecular weight: 81,633 Da
Basal Isoelectric point: 8.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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