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EMR3 Receptor probably involved in myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of momocytes- derived macrophages and activated neutrophils. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 19p13.12
Cellular Component: extracellular region; integral component of membrane; plasma membrane; secretory granule membrane
Molecular Function: calcium ion binding; G-protein coupled receptor activity
Biological Process: cell surface receptor signaling pathway; G-protein coupled receptor signaling pathway; neutrophil degranulation
Reference #:  Q9BY15 (UniProtKB)
Alt. Names/Synonyms: egf-like module containing, mucin-like, hormone receptor-like 3; EGF-like module receptor 3; EGF-like module-containing mucin-like hormone receptor-like 3; EGF-like module-containing mucin-like hormone receptor-like 3 subunit alpha; EGF-like module-containing mucin-like hormone receptor-like 3 subunit beta; egf-like module-containing mucin-like receptor 3; EMR3
Gene Symbols: ADGRE3
Molecular weight: 72,621 Da
Basal Isoelectric point: 8.41  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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