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TSPAN32 This gene, which is a member of the tetraspanin superfamily, is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4, escapes imprinting. This gene may play a role in malignancies and diseases that involve this region, and it is also involved in hematopoietic cell function. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: cell surface; integral component of plasma membrane; intracellular
Biological Process: cell surface receptor signaling pathway; cell-cell signaling; cytoskeleton organization; defense response to protozoan; integrin-mediated signaling pathway; negative regulation of cell proliferation; negative regulation of myeloid dendritic cell activation; regulation of defense response to virus
Reference #:  Q96QS1 (UniProtKB)
Alt. Names/Synonyms: ART1; FLJ17158; FLJ97586; MGC22455; pan-hematopoietic expression protein; PHEMX; PHMX; Q96QS1; Q96QS1-2; Q96QS1-3; tetraspanin 32; tetraspanin-32; TSPAN32; TSSC6; tumor-suppressing STF cDNA 6; tumor-suppressing subchromosomal transferable fragment cDNA 6; tumor-suppressing subtransferable candidate 6
Gene Symbols: TSPAN32
Molecular weight: 34,631 Da
Basal Isoelectric point: 8.81  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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