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ZP3 The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. Belongs to the ZP domain family. ZPC subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Extracellular matrix; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: cytoplasm; endoplasmic reticulum; extracellular matrix; extracellular region; extracellular space; Golgi apparatus; multivesicular body; perinuclear region of cytoplasm; plasma membrane; secretory granule
Molecular Function: acrosin binding; carbohydrate binding; manganese ion transmembrane transporter activity; protein binding
Biological Process: binding of sperm to zona pellucida; blastocyst formation; humoral immune response mediated by circulating immunoglobulin; manganese ion transport; negative regulation of transcription, DNA-dependent; oocyte development; phosphoinositide-mediated signaling; positive regulation of humoral immune response; positive regulation of inflammatory response; positive regulation of interferon-gamma production; positive regulation of interleukin-4 production; positive regulation of leukocyte migration; positive regulation of phosphatidylinositol biosynthetic process; positive regulation of T cell proliferation; positive regulation of transcription, DNA-dependent; positive regulation of type IV hypersensitivity; regulation of intracellular protein transport
Reference #:  P21754 (UniProtKB)
Alt. Names/Synonyms: P21754; P21754-2; P21754-3; zona pellucida glycoprotein 3; zona pellucida glycoprotein 3 (sperm receptor); zona pellucida glycoprotein 3A (sperm receptor); zona pellucida glycoprotein 3B; zona pellucida protein C; zona pellucida sperm-binding protein 3; zona pellucida sperm-binding protein 3 isoform 1; zona pellucida sperm-binding protein 3 isoform 2; ZP3; ZP3A; ZP3B; ZPC
Gene Symbols: ZP3
Molecular weight: 47,018 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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