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TRAF3IP2 Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK. Defects in TRAF3IP2 are the cause of susceptibility to psoriasis type 13 (PSORS13). PSORS13 is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: intracellular
Molecular Function: protein binding; receptor binding
Biological Process: B cell apoptosis; humoral immune response; immunoglobulin secretion; positive regulation of defense response to virus by host; positive regulation of I-kappaB kinase/NF-kappaB signaling
Disease: Candidiasis, Familial, 8; Psoriasis 13, Susceptibility To
Reference #:  O43734 (UniProtKB)
Alt. Names/Synonyms: ACT1; adapter protein CIKS isoform 2; C6orf2; C6orf4; C6orf5; C6orf6; CIKS; connection to IKK and SAPK/JNK; DKFZp586G0522; MGC3581; NFkB-activating protein ACT1; O43734; O43734-2; OTTHUMP00000017022; OTTHUMP00000017024; OTTHUMP00000040422; TRAF3 interacting protein 2; TRAF3IP2
Gene Symbols: TRAF3IP2
Molecular weight: 64,666 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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