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DOR-1 delta opioid receptor, a G-protein coupled receptor. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. Receptor for enkephalins. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 1p35.3
Cellular Component: integral to plasma membrane; intrinsic to plasma membrane; neuron projection; plasma membrane
Molecular Function: neuropeptide binding; opioid receptor activity; protein binding
Biological Process: activation of CREB transcription factor; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); immune response; negative regulation of protein oligomerization; neuropeptide signaling pathway; positive regulation of peptidyl-serine phosphorylation; protein import into nucleus, translocation; regulation of mitochondrial membrane potential; sensory perception of pain; synaptic transmission
Reference #:  P41143 (UniProtKB)
Alt. Names/Synonyms: D-OR-1; delta opioid receptor 1; Delta-type opioid receptor; DOR-1; opioid receptor, delta 1; OPRD; OPRD1
Gene Symbols: OPRD1
Molecular weight: 40,369 Da
Basal Isoelectric point: 9.21  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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