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CRYAB a major structural protein of the eye lens. A member of the small heat shock protein (sHSP also known as the HSP20) family. Alpha-B is expressed in the lens as well as other tissues. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Note: This description may include information from UniProtKB.
Protein type: Chaperone; Heat shock protein
Chromosomal Location of Human Ortholog: 9 A5.3|9 27.75 cM
Cellular Component: actin filament bundle; axon; cell surface; contractile fiber; cytoplasm; cytosol; dendritic spine; extracellular exosome; Golgi apparatus; I band; M band; microtubule cytoskeleton; mitochondrion; myelin sheath; nucleus; perikaryon; plasma membrane; postsynaptic density; synapse; Z disc
Molecular Function: cytoskeletal protein binding; identical protein binding; metal ion binding; microtubule binding; protein binding; protein complex binding; protein homodimerization activity; structural constituent of eye lens; unfolded protein binding
Biological Process: camera-type eye development; cellular response to gamma radiation; lens development in camera-type eye; microtubule polymerization or depolymerization; muscle organ development; negative regulation of amyloid fibril formation; negative regulation of apoptosis; negative regulation of cell growth; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of gene expression; negative regulation of intracellular transport; negative regulation of protein homooligomerization; negative regulation of reactive oxygen species metabolic process; protein folding; protein homooligomerization; protein stabilization; regulation of cell death; response to hydrogen peroxide; response to hypoxia; stress-activated MAPK cascade; tubulin folding
Reference #:  P23927 (UniProtKB)
Alt. Names/Synonyms: alpha B-crystallin; Alpha(B)-crystallin; Alpha-crystallin B chain; Crya-2; Crya2; Cryab; crystallin, alpha 2; crystallin, alpha B; HspB5; P23
Gene Symbols: Cryab
Molecular weight: 20,069 Da
Basal Isoelectric point: 6.76  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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