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TBK1 a protein kinase of the IKK family. Can mediate NFkB activation in response to certain growth factors. Forms a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK. Note: This description may include information from UniProtKB.
Protein type: EC; IKK family; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 10|10 D2
Cellular Component: cytoplasm
Molecular Function: ATP binding; kinase activity; nucleic acid binding; nucleotide binding; phosphoprotein binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process: activation of innate immune response; defense response to Gram-positive bacterium; defense response to virus; dendritic cell proliferation; immune system process; innate immune response; negative regulation of gene expression; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of interferon-alpha production; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-beta production; positive regulation of macroautophagy; positive regulation of transcription from RNA polymerase II promoter; positive regulation of xenophagy; protein amino acid phosphorylation
Reference #:  Q9WUN2 (UniProtKB)
Alt. Names/Synonyms: 1200008B05Rik; AI462036; AW048562; MGC150301; MGC150302; serine/threonine protein kinase TBK1; Serine/threonine-protein kinase TBK1; T2K; TANK-binding kinase 1; Tbk1
Gene Symbols: Tbk1
Molecular weight: 83,425 Da
Basal Isoelectric point: 6.4  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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