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UGCGL2 Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. Belongs to the glycosyltransferase 8 family. Note: This description may include information from UniProtKB.
Protein type: EC 2.4.1.-; Transferase
Chromosomal Location of Human Ortholog: 13q32.1
Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum-Golgi intermediate compartment; protein complex
Molecular Function: protein binding; UDP-glucose:glycoprotein glucosyltransferase activity; unfolded protein binding
Biological Process: de novo'posttranslational protein folding; endoplasmic reticulum unfolded protein response; protein N-linked glycosylation via asparagine
Reference #:  Q9NYU1 (UniProtKB)
Alt. Names/Synonyms: FLJ10873; FLJ11485; hUGT2; MGC117360; MGC150689; MGC87276; UDP--Glc:glycoprotein glucosyltransferase 2; UDP-Glc:glycoprotein glucosyltransferase 2; UDP-glucose ceramide glucosyltransferase-like 1; UDP-glucose ceramide glucosyltransferase-like 2; UDP-glucose glycoprotein glucosyltransferase 2; UDP-glucose:glycoprotein glucosyltransferase 2; UGCGL2; UGGG2; UGGT2; UGT2
Gene Symbols: UGGT2
Molecular weight: 174,735 Da
Basal Isoelectric point: 6.43  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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