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Protein Page:
beclin 1

beclin 1 an essential autophagy protein that has been linked to multiple processes including tumor suppression, protection against some cardiac and neurological degenerative diseases, and lifespan extension. A ubiquitous protein of the beclin family. Is part of the class III PI3K complex that induces autophagy. Expressed at elevated levels in dendrites and cell bodies of cerebellar Purkinje cells. Interacts with the anti-apoptotic protein Bcl-2, which inhibits autophagy when it is present in the endoplasmic reticulum. The dissociation of ATG6 from Bcl-2 is essential for its autophagic activity. Interacts with PITC and GluR-delta2. Probably forms a complex with AMBRA1 and PIK3C3. Plays a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Autophagy; Membrane protein, peripheral
Chromosomal Location of Human Ortholog: 17q21.31
Cellular Component: autophagic vacuole; cytosol; dendrite; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; endosome membrane; extrinsic component of membrane; mitochondrial membrane; mitochondrion; nucleus; phagocytic vesicle; protein complex; trans-Golgi network
Molecular Function: GTPase binding; phosphoinositide 3-kinase binding; protein binding; ubiquitin protein ligase binding
Biological Process: aging; apoptosis; autophagosome assembly; autophagy; beta-amyloid metabolic process; cellular defense response; cellular response to amino acid starvation; cellular response to glucose starvation; cellular response to nitrogen starvation; CVT pathway; cytokinesis; defense response to virus; early endosome to late endosome transport; engulfment of apoptotic cell; late endosome to vacuole transport; lysosome organization and biogenesis; macroautophagy; macromitophagy; mitochondrion degradation; mitotic metaphase plate congression; negative regulation of apoptosis; negative regulation of cell proliferation; neuron development; positive regulation of phosphoinositide 3-kinase cascade; protein deubiquitination; receptor catabolic process; regulation of catalytic activity; regulation of cytokinesis; response to drug; response to hypoxia; response to iron(II) ion; response to lead ion; response to vitamin E; viral process
Reference #:  Q14457 (UniProtKB)
Alt. Names/Synonyms: ATG6; ATG6 autophagy related 6 homolog; beclin 1 (coiled-coil, moesin-like BCL2 interacting protein); beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin 1, autophagy related; Beclin-1; beclin1; BECN1; Coiled-coil myosin-like BCL2-interacting protein; GT197; Protein GT197; VPS30
Gene Symbols: BECN1
Molecular weight: 51,896 Da
Basal Isoelectric point: 4.83  Predict pI for various phosphorylation states
CST Pathways:  Autophagy Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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beclin 1

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