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Claudin-14 Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Defects in CLDN14 are the cause of deafness autosomal recessive type 29 (DFNB29). DFNB29 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the claudin family. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 21q22.13
Cellular Component: bicellular tight junction; endoplasmic reticulum; integral component of membrane; plasma membrane
Molecular Function: identical protein binding; structural molecule activity
Biological Process: calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; protein complex assembly
Disease: Deafness, Autosomal Recessive 29
Reference #:  O95500 (UniProtKB)
Alt. Names/Synonyms: claudin 14; Claudin-14; claudin14; CLD14; CLDN14; DFNB29
Gene Symbols: CLDN14
Molecular weight: 25,699 Da
Basal Isoelectric point: 8.94  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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