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IL1B Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Monomer. Belongs to the IL-1 family. Note: This description may include information from UniProtKB.
Protein type: Cytokine
Chromosomal Location of Human Ortholog: 2q14.1
Cellular Component: cytosol; extracellular region; extracellular space
Molecular Function: cytokine activity; interleukin-1 receptor binding; protein domain specific binding
Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; apoptosis; cell-cell signaling; cytokine and chemokine mediated signaling pathway; embryo implantation; fever; hyaluronan biosynthetic process; inflammatory response; lipopolysaccharide-mediated signaling pathway; MAPKKK cascade; negative regulation of cell proliferation; negative regulation of insulin receptor signaling pathway; negative regulation of lipid catabolic process; negative regulation of lipid metabolic process; negative regulation of MAP kinase activity; negative regulation of synaptic transmission; positive regulation of angiogenesis; positive regulation of fever; positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of heterotypic cell-cell adhesion; positive regulation of interferon-gamma production; positive regulation of interleukin-2 biosynthetic process; positive regulation of interleukin-6 production; positive regulation of interleukin-8 production; positive regulation of lipid catabolic process; positive regulation of membrane protein ectodomain proteolysis; positive regulation of mitosis; positive regulation of NF-kappaB import into nucleus; positive regulation of nitric oxide biosynthetic process; positive regulation of phagocytosis; positive regulation of prostaglandin secretion; positive regulation of protein amino acid phosphorylation; positive regulation of T cell mediated immunity; positive regulation of T cell proliferation; positive regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; positive regulation of vascular endothelial growth factor receptor signaling pathway; protein kinase B signaling cascade; regulation of I-kappaB kinase/NF-kappaB cascade; regulation of insulin secretion; regulation of nitric-oxide synthase activity; sequestering of triacylglycerol; signal transduction
Disease: Gastric Cancer, Hereditary Diffuse
Reference #:  P01584 (UniProtKB)
Alt. Names/Synonyms: Catabolin; IL-1; IL-1 beta; IL1-BETA; IL1B; IL1F2; interleukin 1, beta; Interleukin-1 beta; preinterleukin 1 beta; pro-interleukin-1-beta
Gene Symbols: IL1B
Molecular weight: 30,748 Da
Basal Isoelectric point: 4.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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