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ENPEP Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells. Belongs to the peptidase M1 family. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Protease
Chromosomal Location of Human Ortholog: 4q25
Cellular Component: apical part of cell; apical plasma membrane; brush border; cytoplasmic vesicle; external side of plasma membrane; integral component of plasma membrane; lysosomal membrane; plasma membrane
Molecular Function: aminopeptidase activity; metallopeptidase activity; peptide binding; zinc ion binding
Biological Process: angiogenesis; angiotensin catabolic process in blood; angiotensin maturation; cell migration; cell proliferation; cell-cell signaling; glomerulus development; peptide catabolic process; regulation of systemic arterial blood pressure by renin-angiotensin
Reference #:  Q07075 (UniProtKB)
Alt. Names/Synonyms: Aminopeptidase A; AMPE; AP-A; APA; CD249; Differentiation antigen gp160; EAP; ENPEP; Glutamyl aminopeptidase; glutamyl aminopeptidase (aminopeptidase A); gp160
Gene Symbols: ENPEP
Molecular weight: 109,244 Da
Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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