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CYP2C19 Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. Belongs to the cytochrome P450 family. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - retinol; EC; EC; EC; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of Human Ortholog: 10q23.33
Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle
Molecular Function: (S)-limonene 6-monooxygenase activity; (S)-limonene 7-monooxygenase activity; arachidonic acid epoxygenase activity; enzyme binding; heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity; oxygen binding; steroid hydroxylase activity
Biological Process: drug metabolic process; epoxygenase P450 pathway; exogenous drug catabolic process; heterocycle metabolic process; monoterpenoid metabolic process; steroid metabolic process; xenobiotic metabolic process
Disease: Drug Metabolism, Poor, Cyp2c19-related
Reference #:  P33261 (UniProtKB)
Alt. Names/Synonyms: (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CP2CJ; CPCJ; CYP2C; CYP2C19; CYPIIC17; CYPIIC19; cytochrome P-450 II C; Cytochrome P450 2C19; cytochrome P450, family 2, subfamily C, polypeptide 19; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19; Cytochrome P450-11A; Cytochrome P450-254C; flavoprotein-linked monooxygenase; mephenytoin 4'-hydroxylase; Mephenytoin 4-hydroxylase; microsomal monooxygenase; P450C2C; P450IIC19; S-mephenytoin 4-hydroxylase
Gene Symbols: CYP2C19
Molecular weight: 55,931 Da
Basal Isoelectric point: 7.11  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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