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SGCG Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Defects in SGCG are the cause of limb-girdle muscular dystrophy type 2C (LGMD2C). LGMD2C is characterized by progressive muscle wasting from early childhood. Belongs to the sarcoglycan beta/delta/gamma/zeta family. Note: This description may include information from UniProtKB.
Protein type: Dystrophin complex; Membrane protein, integral
Chromosomal Location of Human Ortholog: 13q12.12
Cellular Component: cytoplasm; cytoskeleton; integral component of membrane; nucleoplasm; plasma membrane; sarcoglycan complex; sarcolemma
Molecular Function: protein binding
Biological Process: cardiac muscle tissue development; heart contraction; muscle cell development; muscle organ development
Disease: Muscular Dystrophy, Limb-girdle, Type 2c
Reference #:  Q13326 (UniProtKB)
Gene Symbols: SGCG
Molecular weight: 32,379 Da
Basal Isoelectric point: 5.64  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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