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Protein Page:
HCRT

Overview
HCRT Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. Defects in HCRT are the cause of narcolepsy type 1 (NRCLP1). Narcolepsy is a neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, such as cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Human narcolepsy is associated with a deficient orexin system. Orexins are absent and/or greatly diminished in the brain and cerebrospinal fluid (CSF) of most narcoleptic patients. Belongs to the orexin family. Note: This description may include information from UniProtKB.
Protein type: Hormone
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component: extracellular region; synaptic vesicle
Biological Process: synaptic transmission
Disease: Narcolepsy 1
Reference #:  O43612 (UniProtKB)
Alt. Names/Synonyms: hypocretin; hypocretin (orexin) neuropeptide precursor; NRCLP1; orexin; OX; PPOX
Gene Symbols: HCRT
Molecular weight: 13,363 Da
Basal Isoelectric point: 10.8  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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HCRT

Protein Structure Not Found.
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