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ATP6V0B Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the V-ATPase proteolipid subunit family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Transporter, iron
Chromosomal Location of Human Ortholog: 1p34.1
Cellular Component: endosome membrane; integral component of membrane; phagocytic vesicle membrane
Molecular Function: hydrogen ion transporting ATPase activity, rotational mechanism; transporter activity
Biological Process: ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; proton transport; regulation of macroautophagy; transferrin transport; vacuolar acidification
Reference #:  Q99437 (UniProtKB)
Gene Symbols: ATP6V0B
Molecular weight: 21,406 Da
Basal Isoelectric point: 7.61  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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