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Protein Page:
DENND4A

Overview
DENND4A an ubiquitous nuclear guanine nucleotide exchange factor (GEF) that activates RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. Highest expression in fetal liver, bone marrow, medium in peripheral blood lymphocytes and lowest in spleen. Induced by serum in low-passage fibroblasts. Expressed at higher levels in normal cells (brain, breast, and prostate) than in tumor cells. Expression is regulated in a growth- and cell cycle-dependent manner. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; GEF; GEF, Rab
Chromosomal Location of Human Ortholog: 15q22.31
Cellular Component: cytosol
Molecular Function: Rab guanyl-nucleotide exchange factor activity
Reference #:  Q7Z401 (UniProtKB)
Alt. Names/Synonyms: c-myc promoter binding protein; C-myc promoter-binding protein; DENN domain-containing protein 4A; DENN/MADD domain containing 4A; DENND4A; FLJ33949; IRLB; KIAA0476; MYCPBP; MYCPP
Gene Symbols: DENND4A
Molecular weight: 209,244 Da
Basal Isoelectric point: 7.07  Predict pI for various phosphorylation states
Select Structure to View Below

DENND4A

Protein Structure Not Found.

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