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OTX2 Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'. Expressed in brain. Belongs to the paired homeobox family. Bicoid subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 14q22.3
Cellular Component: growth cone; nucleus; protein complex
Molecular Function: eukaryotic initiation factor 4E binding; protein binding
Biological Process: axon guidance; forebrain development; midbrain development; positive regulation of embryonic development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; protein complex assembly; regulation of fibroblast growth factor receptor signaling pathway; regulation of smoothened signaling pathway; transcription from RNA polymerase II promoter
Disease: Microphthalmia, Syndromic 5; Pituitary Hormone Deficiency, Combined, 6
Reference #:  P32243 (UniProtKB)
Alt. Names/Synonyms: Homeobox protein OTX2; MCOPS5; MGC45000; orthodenticle homeobox 2; Orthodenticle homolog 2; OTX2
Gene Symbols: OTX2
Molecular weight: 31,636 Da
Basal Isoelectric point: 9.4  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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