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PPP2R2A The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with TP53. Expressed in all tissues examined. Belongs to the phosphatase 2A regulatory subunit B family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 8p21.2
Cellular Component: cytosol; nucleoplasm; protein phosphatase type 2A complex
Molecular Function: protein binding; protein complex binding; protein phosphatase 2A binding; protein phosphatase regulator activity; protein serine/threonine phosphatase activity; tau protein binding
Biological Process: developmental process; G2/M transition of mitotic cell cycle; mitotic cell cycle; mitotic nuclear envelope reassembly; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; protein amino acid dephosphorylation; regulation of catalytic activity; response to morphine
Reference #:  P63151 (UniProtKB)
Alt. Names/Synonyms: 2ABA; B55A; B55ALPHA; DKFZp686N05117; FLJ26613; FLJ41727; MGC52248; PP2A subunit B isoform alpha; PP2A subunit B isoform B55-alpha; PP2A subunit B isoform PR55-alpha; PP2A subunit B isoform R2-alpha; PPP2R2A; PR52A; PR55A; protein phosphatase 2 (formerly 2A), regulatory subunit B (PR52), alpha isoform; protein phosphatase 2, regulatory subunit B, alpha; serine/threonine protein phosphatase 2A, 55 KDA regulatory subunit B, alpha isoform
Gene Symbols: PPP2R2A
Molecular weight: 51,692 Da
Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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