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CCT4 Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. Belongs to the TCP-1 chaperonin family. Note: This description may include information from UniProtKB.
Protein type: Chaperone
Chromosomal Location of Human Ortholog: 14q22
Cellular Component: centrosome; chaperonin-containing T-complex; cilium; cytosol; melanosome; microtubule; nucleoplasm
Molecular Function: ATP binding; RNA binding; unfolded protein binding
Biological Process: binding of sperm to zona pellucida; chaperone cofactor-dependent protein folding; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; protein folding; protein stabilization
Reference #:  Q7TPB1 (UniProtKB)
Alt. Names/Synonyms: CCT-delta; Cct4; chaperonin containing Tcp1, subunit 4 (delta); chaperonin subunit 4 (delta); T-complex protein 1 subunit delta; TCP-1-delta
Gene Symbols: Cct4
Molecular weight: 58,099 Da
Basal Isoelectric point: 8.24  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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