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CAMK1A an ubiquitous protein kinase of the CAMK1 family. Activated by Ca(2+)/calmodulin. Must be phosphorylated to be maximally active. Substrates include synapsin I. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMK1 family; EC; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 3p25.3
Cellular Component: cytoplasm; intracellular; nucleus
Molecular Function: ATP binding; calmodulin binding; calmodulin-dependent protein kinase activity; protein binding
Biological Process: cell cycle; negative regulation of protein binding; nucleocytoplasmic transport; peptidyl-threonine phosphorylation; positive regulation of muscle cell differentiation; positive regulation of neuron projection development; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein acetylation; positive regulation of protein export from nucleus; positive regulation of protein serine/threonine kinase activity; positive regulation of synapse structural plasticity; positive regulation of syncytium formation by plasma membrane fusion; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; regulation of histone H3-K9 acetylation; regulation of muscle cell differentiation; regulation of protein binding; regulation of protein localization; signal transduction
Reference #:  Q14012 (UniProtKB)
Alt. Names/Synonyms: calcium/calmodulin-dependent protein kinase I; Calcium/calmodulin-dependent protein kinase type 1; CaM kinase I; CaM kinase I alpha; CaM-KI; CAMK1; CAMKI; CaMKI-alpha; KCC1A; MGC120317; MGC120318
Gene Symbols: CAMK1
Molecular weight: 41,337 Da
Basal Isoelectric point: 5.12  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Microtubule Dynamics
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