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Protein Page:

RBM17 Splice factor that binds to the single stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 10p15.1
Cellular Component: nucleoplasm; protein complex; spliceosomal complex
Molecular Function: protein binding; RNA binding
Biological Process: alternative mRNA splicing, via spliceosome; DNA repair; mRNA splicing, via spliceosome; regulation of RNA splicing
Reference #:  Q96I25 (UniProtKB)
Alt. Names/Synonyms: 45 kDa-splicing factor; DKFZp686F13131; MGC14439; RBM17; RNA binding motif protein 17; RNA-binding motif protein 17; SPF45; Splicing factor 45; splicing factor 45kDa
Gene Symbols: RBM17
Molecular weight: 44,962 Da
Basal Isoelectric point: 5.76  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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