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TSHZ3 Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up- regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter. Belongs to the teashirt C2H2-type zinc-finger protein family. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 19q12
Cellular Component: nucleoplasm; nucleus
Molecular Function: chromatin binding; protein binding
Biological Process: multicellular organismal development; negative regulation of transcription, DNA-dependent; neurological control of breathing; positive regulation of synaptic transmission, glutamatergic; regulation of transcription from RNA polymerase II promoter
Reference #:  Q63HK5 (UniProtKB)
Alt. Names/Synonyms: FLJ54422; KIAA1474; teashirt 3; teashirt family zinc finger 3; Teashirt homolog 3; teashirt zinc finger homeobox 3; TSH3; TSHZ3; Zinc finger protein 537; ZNF537
Gene Symbols: TSHZ3
Molecular weight: 118,566 Da
Basal Isoelectric point: 6.83  Predict pI for various phosphorylation states
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