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Protein Page:

Insulin Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Heterodimer of a B chain and an A chain linked by two disulfide bonds. Belongs to the insulin family. Note: This description may include information from UniProtKB.
Protein type: Hormone; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 7 F5|7 88.0 cM
Cellular Component: cytoplasm; cytosol; extracellular region; extracellular space; nucleus; secretory granule; small nucleolar ribonucleoprotein complex
Molecular Function: hormone activity; identical protein binding; insulin receptor binding; insulin-like growth factor receptor binding; protease binding; protein complex binding
Biological Process: activation of JNK activity; activation of MAPK activity; activation of protein kinase B activity; acute-phase response; alpha-beta T cell activation; carbohydrate metabolic process; ER overload response; fatty acid homeostasis; G-protein coupled receptor signaling pathway; glucose homeostasis; glucose metabolic process; glucose transport; insulin receptor signaling pathway; lipid catabolic process; MAPK cascade; myoblast fusion; myotube differentiation; negative regulation of acute inflammatory response; negative regulation of fatty acid metabolic process; negative regulation of glycogen catabolic process; negative regulation of lipid catabolic process; negative regulation of NAD(P)H oxidase activity; negative regulation of protein catabolic process; negative regulation of protein oligomerization; negative regulation of protein secretion; negative regulation of proteolysis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell proliferation; positive regulation of cellular protein metabolic process; positive regulation of cytokine secretion; positive regulation of DNA replication; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; positive regulation of glycolysis; positive regulation of insulin receptor signaling pathway; positive regulation of MAPK cascade; positive regulation of mitotic nuclear division; positive regulation of NF-kappaB transcription factor activity; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling; regulation of cellular amino acid metabolic process; regulation of gene expression; regulation of phosphorylation; regulation of protein binding; regulation of protein localization; regulation of protein secretion; regulation of transmembrane transporter activity; Wnt receptor signaling pathway through beta-catenin; wound healing
Reference #:  P01326 (UniProtKB)
Alt. Names/Synonyms: ins-2; ins2; insulin II; insulin-2
Gene Symbols: Ins2
Molecular weight: 12,364 Da
Basal Isoelectric point: 5.2  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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