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IRF8 Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Interacts (via C-terminus) with TRIM21 (via C-terminus). Interacts with COPS2. By IFNG/IFN-gamma. Predominantly expressed in lymphoid tissues. Belongs to the IRF family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 16q24.1
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: protein binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Biological Process: defense response to bacterium; defense response to protozoan; immune response; myeloid cell differentiation; negative regulation of transcription from RNA polymerase II promoter; phagocytosis; positive regulation of interferon-gamma production; positive regulation of interleukin-12 production; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent
Disease: Immunodeficiency 32a; Monocyte And Dendritic Cell Deficiency, Autosomal Recessive
Reference #:  Q02556 (UniProtKB)
Alt. Names/Synonyms: H-ICSBP; ICSBP; ICSBP1; interferon consensus sequence binding protein 1; Interferon consensus sequence-binding protein; Interferon regulatory factor 8; IRF-8; IRF8
Gene Symbols: IRF8
Molecular weight: 48,356 Da
Basal Isoelectric point: 6.38  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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