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Protein Page:
GPR17

Overview
GPR17 Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 18p12
Cellular Component: integral to plasma membrane
Molecular Function: G-protein coupled receptor activity
Biological Process: elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); immune system process; negative regulation of inflammatory response to antigenic stimulus; positive regulation of Rho protein signal transduction
Reference #:  Q09QM4 (UniProtKB)
Alt. Names/Synonyms: G protein-coupled receptor 17; G-protein coupled receptor 17; Gpr17; UDP/CysLT receptor; Uracil nucleotide/cysteinyl leukotriene receptor
Gene Symbols: Gpr17
Molecular weight: 37,870 Da
Basal Isoelectric point: 8.95  Predict pI for various phosphorylation states
Select Structure to View Below

GPR17

Protein Structure Not Found.

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