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K1 a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K10. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component: cornified envelope; cytoskeleton; cytosol; extracellular matrix; extracellular region; extracellular space; keratin filament; membrane; nucleus
Molecular Function: carbohydrate binding; protein binding; receptor activity; structural constituent of epidermis
Biological Process: complement activation, lectin pathway; fibrinolysis; keratinization; negative regulation of inflammatory response; neutrophil degranulation; peptide cross-linking; regulation of angiogenesis; response to oxidative stress; retinal homeostasis
Disease: Epidermolytic Hyperkeratosis; Ichthyosis Hystrix, Curth-macklin Type; Ichthyosis, Cyclic, With Epidermolytic Hyperkeratosis; Keratosis Palmoplantaris Striata Iii; Palmoplantar Keratoderma, Epidermolytic; Palmoplantar Keratoderma, Nonepidermolytic
Reference #:  P04264 (UniProtKB)
Alt. Names/Synonyms: 67 kDa cytokeratin; CK-1; CK1; cytokeratin 1; Cytokeratin-1; EHK; EHK1; epidermolytic hyperkeratosis 1; EPPK; Hair alpha protein; K1; K2C1; keratin 1; Keratin, type II cytoskeletal 1; Keratin-1; KRT1; KRT1A; KRTA; NEPPK; Type-II keratin Kb1
Gene Symbols: KRT1
Molecular weight: 66,039 Da
Basal Isoelectric point: 8.15  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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