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FOXC1 Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Monomer. Expressed in all tissues and cell lines examined. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Cell development/differentiation; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 6p25.3
Cellular Component: cytosol; nuclear heterochromatin; nucleoplasm; nucleus
Molecular Function: DNA bending activity; DNA binding; protein binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor activity; transcription factor binding
Biological Process: cell migration; cell proliferation; cerebellum development; endochondral ossification; eye development; heart development; kidney development; mesenchymal cell development; negative regulation of angiogenesis; negative regulation of mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; odontogenesis of dentine-containing teeth; positive regulation of DNA binding; positive regulation of keratinocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; ureteric bud development
Disease: Axenfeld-rieger Syndrome, Type 3; Iridogoniodysgenesis, Type 1
Reference #:  Q12948 (UniProtKB)
Alt. Names/Synonyms: ARA; FKHL7; forkhead box C1; Forkhead box protein C1; forkhead, drosophila, homolog-like 7; forkhead-related activator 3; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; forkhead/winged helix-like transcription factor 7; FOXC1; FREAC-3; FREAC3; IGDA; IHG1; IRID1; myeloid factor-delta; RIEG3
Gene Symbols: FOXC1
Molecular weight: 56,789 Da
Basal Isoelectric point: 8.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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