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GRHPR Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate. Defects in GRHPR are the cause of hyperoxaluria primary type 2 (HP2); also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L- glycerate. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - glyoxylate and dicarboxylate; Carbohydrate Metabolism - pyruvate; EC; EC; Oxidoreductase
Chromosomal Location of Human Ortholog: 9p13.2
Cellular Component: cytoplasm; cytosol; peroxisomal matrix
Molecular Function: carboxylic acid binding; glycerate dehydrogenase activity; glyoxylate reductase (NADP) activity; hydroxypyruvate reductase activity; NAD binding; protein homodimerization activity
Biological Process: dicarboxylic acid metabolic process; excretion; metabolic process; protein oligomerization
Disease: Hyperoxaluria, Primary, Type Ii
Reference #:  Q9UBQ7 (UniProtKB)
Alt. Names/Synonyms: GLXR; glycerate-2-dehydrogenase; GLYD; Glyoxylate reductase/hydroxypyruvate reductase; GRHPR; PH2
Gene Symbols: GRHPR
Molecular weight: 35,668 Da
Basal Isoelectric point: 7.01  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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