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GR transcription factor of the nuclear receptor family. Receptor for glucocorticoids (GC). Binds to glucocorticoid response elements (GRE) and modulates other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor
Chromosomal Location of Human Ortholog: 5q31.3
Cellular Component: cytoplasm; cytosol; microtubule organizing center; mitochondrial matrix; nuclear speck; nucleoplasm; nucleus; protein complex; spindle
Molecular Function: DNA binding transcription factor activity; glucocorticoid receptor activity; glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity; Hsp90 protein binding; protein binding; RNA binding; steroid binding; steroid hormone binding; SUMO binding; zinc ion binding
Biological Process: apoptosis; cell cycle; cell division; cellular response to dexamethasone stimulus; cellular response to glucocorticoid stimulus; cellular response to steroid hormone stimulus; cellular response to transforming growth factor beta stimulus; chromosome segregation; covalent chromatin modification; glucocorticoid mediated signaling pathway; glucocorticoid receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-templated; signal transduction; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent
Disease: Glucocorticoid Resistance, Generalized
Reference #:  P04150 (UniProtKB)
Alt. Names/Synonyms: GCCR; GCR; Glucocorticoid receptor; GR; GRL; NR3C1; Nuclear receptor subfamily 3 group C member 1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Gene Symbols: NR3C1
Molecular weight: 85,659 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.
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