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WRN Multifunctional enzyme that has both magnesium and ATP- dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double- stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Monomer, and homooligomer. May exist as homodimer, homotrimer, homotetramer and/or homohexamer. Homotetramer, or homohexamer, when bound to DNA. Interacts via its N-terminal domain with WRNIP1. Interacts with EXO1, PCNA and SUPV3L1. Belongs to the helicase family. RecQ subfamily. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; DNA repair, damage; DNA-binding; EC; Helicase; Nucleolus
Chromosomal Location of Human Ortholog: 8p12
Cellular Component: centrosome; chromosome, telomeric region; cytoplasm; MutLalpha complex; neuron projection; nuclear speck; nucleolus; nucleoplasm; replication fork
Molecular Function: 3'-5' DNA helicase activity; 3'-5' exonuclease activity; ATP binding; ATP-dependent 3'-5' DNA helicase activity; ATP-dependent DNA helicase activity; ATPase activity; bubble DNA binding; chromatin binding; DNA binding; DNA helicase activity; exonuclease activity; four-way junction DNA binding; four-way junction helicase activity; G-quadruplex DNA binding; helicase activity; magnesium ion binding; manganese ion binding; protein binding; protein complex binding; protein homodimerization activity; Y-form DNA binding
Biological Process: aging; base-excision repair; brain development; cell aging; cellular response to DNA damage stimulus; cellular response to starvation; DNA duplex unwinding; DNA metabolic process; DNA replication; DNA synthesis involved in DNA repair; double-strand break repair; double-strand break repair via homologous recombination; multicellular organismal aging; nucleolus to nucleoplasm transport; positive regulation of hydrolase activity; regulation of apoptosis; regulation of growth rate; replication fork processing; replicative cell aging; response to oxidative stress; response to UV-C; strand displacement; telomere maintenance
Disease: Werner Syndrome
Reference #:  Q14191 (UniProtKB)
Alt. Names/Synonyms: DKFZp686C2056; DNA helicase, RecQ-like type 3; RecQ protein-like 2; RECQ3; RECQL2; RECQL3; Werner syndrome ATP-dependent helicase; Werner syndrome, RecQ helicase-like; WRN
Gene Symbols: WRN
Molecular weight: 162,461 Da
Basal Isoelectric point: 5.96  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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