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PTPN22 Seems to act on Cbl. May play a role in regulating the function of Cbl and its associated protein kinases. Acts as negative regulator of T-cell receptor (TCR) signaling. Dephosphorylates and inactivates the SRC family kinases. Interacts with CSK. Interacts with LPXN. Predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells. Down-regulated by phosphorylation. Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 1p13.2
Cellular Component: cytoplasm; cytoplasmic side of plasma membrane; cytosol; nucleus; perinuclear region of cytoplasm
Molecular Function: kinase binding; phosphoric monoester hydrolase activity; protein binding; protein tyrosine phosphatase activity; SH3 domain binding; ubiquitin protein ligase binding
Biological Process: autophagy; lipopolysaccharide-mediated signaling pathway; negative regulation of autophagy; negative regulation of JNK activity; negative regulation of T cell activation; negative regulation of T cell receptor signaling pathway; negative regulation of tumor necrosis factor production; positive regulation of interferon type I production; positive regulation of toll-like receptor 3 signaling pathway; positive regulation of toll-like receptor 4 signaling pathway; protein amino acid dephosphorylation; regulation of B cell receptor signaling pathway; regulation of innate immune response; regulation of natural killer cell proliferation; response to lipopolysaccharide; T cell differentiation; T cell receptor signaling pathway
Disease: Diabetes Mellitus, Insulin-dependent; Rheumatoid Arthritis; Systemic Lupus Erythematosus
Reference #:  Q9Y2R2 (UniProtKB)
Alt. Names/Synonyms: Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; Lymphoid phosphatase; lymphoid-specific protein tyrosine phosphatase; LyP; LYP1; LYP2; PEP; PEST-domain phosphatase; protein tyrosine phosphatase, non-receptor type 22 (lymphoid); protein tyrosine phosphatase, non-receptor type 8; PTN22; PTPN22; PTPN8; Tyrosine-protein phosphatase non-receptor type 22
Gene Symbols: PTPN22
Molecular weight: 91,705 Da
Basal Isoelectric point: 7.5  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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