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MYBPC3 Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. Belongs to the immunoglobulin superfamily. MyBP family. Note: This description may include information from UniProtKB.
Protein type: Myosin-binding
Chromosomal Location of Human Ortholog: 11p11.2
Cellular Component: A band; cytosol; M band; sarcomere; striated muscle thick filament; Z disc
Molecular Function: actin filament binding; ATPase activator activity; identical protein binding; muscle alpha-actinin binding; myosin binding; myosin heavy chain binding; protein binding; structural constituent of muscle
Biological Process: actin filament organization; cardiac muscle contraction; heart morphogenesis; muscle filament sliding; positive regulation of ATPase activity; regulation of muscle filament sliding; regulation of striated muscle contraction; sarcomere organization; striated muscle contraction; ventricular cardiac muscle morphogenesis
Disease: Cardiomyopathy, Familial Hypertrophic, 4; Left Ventricular Noncompaction 10
Reference #:  Q14896 (UniProtKB)
Alt. Names/Synonyms: C-protein, cardiac muscle isoform; Cardiac MyBP-C; CMH4; DKFZp779E1762; FHC; MYBP-C; MYBPC3; myosin binding protein C, cardiac; myosin-binding protein C, cardiac; Myosin-binding protein C, cardiac-type; MYPC3
Gene Symbols: MYBPC3
Molecular weight: 140,762 Da
Basal Isoelectric point: 6.24  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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