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Protein Page:
CELF4

Overview
CELF4 RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Belongs to the CELF/BRUNOL family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: RNA splicing
Chromosomal Location of Human Ortholog: 18q12.2
Molecular Function: BRE binding
Biological Process: alternative nuclear mRNA splicing, via spliceosome; positive regulation of nuclear mRNA splicing, via spliceosome; regulation of alternative nuclear mRNA splicing, via spliceosome
Reference #:  Q9BZC1 (UniProtKB)
Alt. Names/Synonyms: Bruno -like 4, RNA binding protein; bruno-like 4, RNA binding protein; Bruno-like protein 4; BRUNOL-4; BRUNOL4; CELF-4; CELF4; CUG-BP and ETR-3 like factor 4; CUG-BP- and ETR-3-like factor 4; CUGBP Elav-like family member 4; CUGBP, Elav-like family member 4; LYST-interacting protein LIP9; RNA-binding protein BRUNOL-4; RNA-binding protein BRUNOL4
Gene Symbols: CELF4
Molecular weight: 51,966 Da
Basal Isoelectric point: 8.11  Predict pI for various phosphorylation states
Select Structure to View Below

CELF4

Protein Structure Not Found.
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