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KRas Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Interacts with PHLPP. Interacts (active GTP-bound form preferentially) with RGS14. Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP). Belongs to the small GTPase superfamily. Ras family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 12p12.1
Cellular Component: cytoplasm; cytosol; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; membrane; membrane raft; mitochondrion; plasma membrane
Molecular Function: GDP binding; GMP binding; GTP binding; GTPase activity; LRR domain binding; protein binding; protein complex binding
Biological Process: actin cytoskeleton organization; axon guidance; cytokine-mediated signaling pathway; epidermal growth factor receptor signaling pathway; female pregnancy; forebrain astrocyte development; homeostasis of number of cells within a tissue; leukocyte migration; liver development; MAPK cascade; negative regulation of cell differentiation; negative regulation of neuron apoptosis; positive regulation of cell proliferation; positive regulation of MAP kinase activity; positive regulation of NF-kappaB transcription factor activity; positive regulation of nitric-oxide synthase activity; positive regulation of protein phosphorylation; positive regulation of Rac protein signal transduction; Ras protein signal transduction; regulation of long-term neuronal synaptic plasticity; regulation of protein stability; regulation of synaptic transmission, GABAergic; response to glucocorticoid stimulus; response to mineralocorticoid stimulus; stimulatory C-type lectin receptor signaling pathway; striated muscle cell differentiation; visual learning
Disease: Bladder Cancer; Breast Cancer; Cardiofaciocutaneous Syndrome 2; Gastric Cancer, Hereditary Diffuse; Leukemia, Acute Myeloid; Lung Cancer; Noonan Syndrome 3; Pancreatic Cancer; Schimmelpenning-feuerstein-mims Syndrome
Reference #:  P01116 (UniProtKB)
Alt. Names/Synonyms: c-K-ras; c-Ki-ras; c-Kirsten-ras protein; cellular c-Ki-ras2 proto-oncogene; GTPase KRas; GTPase KRas, N-terminally processed; K-Ras; K-Ras 2; K-ras p21 protein; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; Ki-Ras; Kirsten rat sarcoma-2 viral (v-Ki-ras2) oncogene homolog; KRAS; KRAS1; KRAS2; NS; NS3; oncogene KRAS2; PR310 c-K-ras oncogene; RASK; RASK2; transforming protein p21; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Gene Symbols: KRAS
Molecular weight: 21,656 Da
Basal Isoelectric point: 6.33  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Angiogenesis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  NF-kB Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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