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HAND1 Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'- NRTCTG-3' (non-canonical E-box). Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; DNA-binding; Nucleolus; Transcription factor
Chromosomal Location of Human Ortholog: 5q33.2
Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleus
Molecular Function: bHLH transcription factor binding; enzyme binding; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; transcription coactivator activity; transcription corepressor activity; transcription factor binding
Biological Process: angiogenesis; blastocyst development; embryonic heart tube development; heart development; heart looping; mesoderm formation; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; odontogenesis of dentine-containing teeth; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; trophectodermal cell differentiation; ventricular cardiac muscle tissue morphogenesis
Reference #:  O96004 (UniProtKB)
Alt. Names/Synonyms: BHLHA27; Class A basic helix-loop-helix protein 27; EHAND; Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; HAND1; heart and neural crest derivatives expressed 1; Heart- and neural crest derivatives-expressed protein 1; Hxt; Thing1
Gene Symbols: HAND1
Molecular weight: 23,627 Da
Basal Isoelectric point: 9.69  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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