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ADAM22 Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q21.12
Cellular Component: axon; integral component of membrane; plasma membrane
Molecular Function: integrin binding; metalloendopeptidase activity; protein binding
Biological Process: adult locomotory behavior; cell adhesion; central nervous system development; myelination in the peripheral nervous system; negative regulation of cell adhesion; proteolysis
Reference #:  Q9P0K1 (UniProtKB)
Alt. Names/Synonyms: a disintegrin and metalloproteinase domain 22; ADA22; ADAM 22; ADAM metallopeptidase domain 22; ADAM22; Disintegrin and metalloproteinase domain-containing protein 22; MDC2; Metalloproteinase-disintegrin ADAM22-3; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2; MGC149832
Gene Symbols: ADAM22
Molecular weight: 100,433 Da
Basal Isoelectric point: 6.91  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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