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KCC3 Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells. Homomultimer and heteromultimer with other K-Cl cotransporters. Up-regulated by VEGF. Down-regulated by TNF. Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas. Detected in umbilical vein endothelial cells. Isoform 2 is more abundant in kidney. Isoform 5 is testis specific. Expressed in the proximal tubule of the kidney. Activated by N-ethylmaleimide (NEM). Inhibited by DIOA, bumetanide and furosemide. Inhibited by WNK3. Belongs to the SLC12A transporter family. 6 isoforms of the human protein are produced by alternative promoter. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 15q14
Cellular Component: basolateral plasma membrane; plasma membrane
Molecular Function: potassium ion symporter activity; potassium:chloride symporter activity
Biological Process: ion transport; synaptic transmission
Disease: Agenesis Of The Corpus Callosum With Peripheral Neuropathy
Reference #:  Q9UHW9 (UniProtKB)
Alt. Names/Synonyms: ACCPN; DKFZp434D2135; Electroneutral potassium-chloride cotransporter 3; K-Cl cotransporter 3; KCC3; KCC3A; KCC3B; potassium chloride cotransporter 3; potassium chloride cotransporter KCC3a-S3; potassium-chloride transporter-3a; potassium-chloride transporter-3b; S12A6; SLC12A6; solute carrier family 12 (potassium/chloride transporters), member 6; Solute carrier family 12 member 6
Gene Symbols: SLC12A6
Molecular weight: 127,617 Da
Basal Isoelectric point: 6.64  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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