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JNK2 a protein kinase of the MAPK family that is potently activated by a variety of environmental stresses including UV radiation. Phosphorylates specific transcription factors such as c-Jun and ATF2, mediating immediate-early gene expression. Closely related to JNK1. Both are involved in UV radiation induced apoptosis. Blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells in the mouse. Four alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: CMGC group; EC; JNK subfamily; Kinase, protein; MAPK family; MAPK/JNK subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 5q35.3
Cellular Component: cytoplasm; cytosol; mitochondrion; neuron projection; nucleoplasm; nucleus
Molecular Function: ATP binding; JUN kinase activity; protein binding; transcription factor binding
Biological Process: cellular response to cadmium ion; cellular response to organic substance; cellular response to reactive oxygen species; Fc-epsilon receptor signaling pathway; JNK cascade; JUN phosphorylation; neuron development; peptidyl-serine phosphorylation; positive regulation of apoptosis; positive regulation of apoptotic signaling pathway; positive regulation of gene expression; positive regulation of macrophage derived foam cell differentiation; positive regulation of podosome assembly; protein amino acid phosphorylation; protein localization to tricellular tight junction; regulation of circadian rhythm; regulation of transcription factor activity; response to mechanical stimulus; response to stress; rhythmic process
Reference #:  P45984 (UniProtKB)
Alt. Names/Synonyms: c-Jun kinase 2; c-Jun N-terminal kinase 2; JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; Jun kinase; MAP kinase 9; MAPK 9; MAPK9; Mitogen-activated protein kinase 9; mitogen-activated protein kinase 9 isoform JNK2 alpha2; MK09; p54a; p54aSAPK; PRKM9; SAPK; Stress-activated protein kinase JNK2
Gene Symbols: MAPK9
Molecular weight: 48,139 Da
Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Mitochondrial Control of Apoptosis  |  NF-kB Signaling  |  Parkinson's Disease  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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