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DNAJC5 a cysteine string protein that inhibits N-type calcium channels which is blocked by huntingtin mutants. May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings. Modulates the maturation of cystic fibrosis transmembrane conductance regulator. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 20q13.33
Cellular Component: extracellular exosome; lysosomal membrane; melanosome; membrane; mitochondrion; plasma membrane; synaptic vesicle; terminal bouton
Molecular Function: ATP-dependent protein binding
Biological Process: exocytosis; negative regulation of neuron apoptosis; neurotransmitter secretion; neutrophil degranulation; regulated secretory pathway; synaptic vesicle exocytosis
Reference #:  Q9H3Z4 (UniProtKB)
Alt. Names/Synonyms: CSP; Cysteine string protein; DKFZp434N1429; DKFZp761N1221; DnaJ (Hsp40) homolog, subfamily C, member 5; DnaJ homolog subfamily C member 5; DNAJC5; DNAJC5A; DNJC5; FLJ00118; FLJ13070
Gene Symbols: DNAJC5
Molecular weight: 22,149 Da
Basal Isoelectric point: 4.93  Predict pI for various phosphorylation states
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