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Oct2 Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter. Belongs to the POU transcription factor family. Class- 2 subfamily. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: cytoplasm; intracellular membrane-bound organelle; nucleoplasm; nucleus
Molecular Function: DNA binding transcription factor activity; protein domain specific binding; sequence-specific DNA binding
Biological Process: cell maturation; humoral immune response; immunoglobulin secretion during immune response; mature B cell differentiation; positive regulation of transcription from RNA polymerase II promoter; snRNA transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter
Reference #:  P09086 (UniProtKB)
Alt. Names/Synonyms: homeobox protein; Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; Oct-2; OCT2; Octamer-binding protein 2; Octamer-binding transcription factor 2; OTF-2; OTF2; PO2F2; POU class 2 homeobox 2; POU domain, class 2, transcription factor 2; POU2F2
Gene Symbols: POU2F2
Molecular weight: 51,209 Da
Basal Isoelectric point: 8.6  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling
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