Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: cytoplasm; endoplasmic reticulum; Golgi apparatus; intracellular membrane-bound organelle; mitochondrion; perinuclear region of cytoplasm
Molecular Function: protein binding; signal transducer activity; WW domain binding
Biological Process: negative regulation of protein transport; negative regulation of transporter activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein ubiquitination
Alt. Names/Synonyms: FLJ25842; KIAA1165; MAPK-activating protein PM04 PM05 PM06 PM07; N4WBP5A; NDFIP2; Nedd4 family interacting protein 2; NEDD4 family-interacting protein 2; NEDD4 WW domain-binding protein 5A; NF-kappa-B-activating protein 413; NFIP2; Putative MAPK-activating protein PM04/PM05/PM06/PM07; Putative NF-kappa-B-activating protein 413