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POU6F2 Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA. Defects in POU6F2 are a cause of hereditary susceptibility to Wilms tumor 5 (WT5). WT5 is a pediatric malignancy of kidney and one of the most common solid cancers in childhood. Belongs to the POU transcription factor family. Class- 6 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 7p14.1
Cellular Component: nucleus
Molecular Function: transcription factor activity
Biological Process: central nervous system development; ganglion mother cell fate determination; regulation of transcription, DNA-dependent; visual perception
Disease: Wilms Tumor 5
Reference #:  P78424 (UniProtKB)
Alt. Names/Synonyms: POU class 6 homeobox 2; POU domain, class 6, transcription factor 2; POU6F2; retina-derived POU domain factor 1; retina-derived POU-domain factor-1; RPF-1; Wilms tumor suppressor locus; WT5; WTSL
Gene Symbols: POU6F2
Molecular weight: 73,265 Da
Basal Isoelectric point: 7.31  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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