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Snail2 Transcriptional repressor. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains). Expressed in placenta and adult heart, pancreas, liver, kidney and skeletal muscle. Belongs to the snail C2H2-type zinc-finger protein family. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor
Chromosomal Location of Human Ortholog: 8q11.21
Cellular Component: nuclear chromatin; nucleus
Molecular Function: protein binding; sequence-specific DNA binding
Biological Process: epithelial to mesenchymal transition; negative regulation of cell adhesion mediated by integrin; negative regulation of chondrocyte differentiation; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of transcription from RNA polymerase II promoter; neural crest cell development; Notch signaling pathway; osteoblast differentiation; pigmentation; positive regulation of cell migration; regulation of chemokine production; regulation of osteoblast differentiation; sensory perception of sound; Wnt receptor signaling pathway through beta-catenin
Disease: Piebald Trait; Waardenburg Syndrome, Type 2d
Reference #:  O43623 (UniProtKB)
Alt. Names/Synonyms: MGC10182; Neural crest transcription factor Slug; Protein snail homolog 2; SLUG; slug (chicken homolog), zinc finger protein; SLUGH; SLUGH1; SNAI2; snail 2; snail homolog 2 (Drosophila); WS2D; Zinc finger protein SNAI2
Gene Symbols: SNAI2
Molecular weight: 29,986 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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