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K3 a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K12. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component: cytosol; intermediate filament; keratin filament
Molecular Function: structural molecule activity
Biological Process: epithelial cell differentiation; intermediate filament cytoskeleton organization and biogenesis; keratinization
Disease: Corneal Dystrophy, Meesmann
Reference #:  P12035 (UniProtKB)
Alt. Names/Synonyms: 65 kDa cytokeratin; CK-3; CK3; cytokeratin 3; Cytokeratin-3; FLJ95909; K2C3; K3; keratin 3; Keratin, type II cytoskeletal 3; Keratin-3; KRT3; Type-II keratin Kb3
Gene Symbols: KRT3
Molecular weight: 64,417 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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