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AP1M1 Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Belongs to the adaptor complexes medium subunit family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 19p13.11
Cellular Component: clathrin adaptor complex; cytoplasmic vesicle membrane; cytosol; Golgi membrane; lysosomal membrane; membrane; plasma membrane; trans-Golgi network membrane
Molecular Function: protein binding
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; intracellular protein transport; melanosome organization; neutrophil degranulation; regulation of defense response to virus by virus
Reference #:  Q9BXS5 (UniProtKB)
Alt. Names/Synonyms: Adaptor protein complex AP-1 mu-1 subunit; Adaptor-related protein complex 1 mu-1 subunit; adaptor-related protein complex 1, mu 1 subunit; AP-1 complex subunit mu-1; AP-mu chain family member mu1A; AP1M1; AP47; CLAPM2; clathrin adaptor protein AP47; Clathrin assembly protein complex 1 medium chain 1; clathrin assembly protein complex 1, medium chain; clathrin assembly protein complex AP1, mu subunit; Clathrin coat assembly protein AP47; Clathrin coat-associated protein AP47; CLTNM; golgi adaptor AP-1 47 kDa protein; Golgi adaptor HA1/AP1 adaptin mu-1 subunit; HA1 47 kDa subunit; MU-1A; Mu-adaptin 1; Mu1A-adaptin
Gene Symbols: AP1M1
Molecular weight: 48,587 Da
Basal Isoelectric point: 6.82  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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